Iron deposition in deep nuclei associated with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study

Motivation: To explore iron metabolism biomarkers associated with cognitive dysfunction in patients with CSVD, addressing the need for reliable diagnostic indicators. Goal(s): To quantify iron deposition in deep nuclei with quantitative susceptibility mapping and to evaluate its relationship with cognitive dysfunction Approach: Applied quantitative susceptibility mapping to assess iron deposition in deep nuclei, and utilized statistical analyses including ANOVA, Bonferroni correction, and Spearman's correlation to evaluate the relationship between susceptibility values and cognitive performance as measured by MoCA scores Results: Iron deposition in the right putamen may serve as a biomarker for cognitive dysfunction in CSVD Impact: It demonstrates the association between iron deposition in deep nuclei and cognitive dysfunction in CSVD, providing evidence for iron deposition in specific regions as a diagnostic marker and insight into the mechanisms of cognitive dysfunction, which guide future therapeutic strategies.