Initial Experiences with Hyperpolarized [1-13C] Pyruvate MRI In Hepatocellular Carcinoma Patients
Motivation: To offer patients curative treatment for hepatocellular carcinoma (HCC) it is crucial to make the diagnosis as early as possible. The sensitivity for diagnosis of HCC smaller than 1 cm with traditionally MRI is low. Goal(s): We aim to investigate if adding hyperpolarized [1-13C] pyruvate to the conventional MRI exam can improve the diagnosis and aggressiveness assessment of HCC by characterizing tumor metabolism. Approach: We used hyperpolarized [1-13C] pyruvate MRI to assess tumor metabolism in patients with HCC. Results: Results show altered metabolism in confirmed HCC and interestingly a case of glutaminase synthase positive HCC shows increased alanine/pyruvate compared to non-tumor liver. Impact: Hyperpolarized MRI in patients with HCC is feasible and may be used to detect early HCC and might characterize glutaminase synthase positive tumors non-invasively by increased alanine production.
Authors
- Nikolaj Bøgh (ORCID: https://orcid.org/0000-0002-0321-3269)
- Uffe Kjærgaard (ORCID: https://orcid.org/0000-0002-9188-2162)
- Steffen Ringgaard (ORCID: https://orcid.org/0000-0001-5353-7379)
- Kim Sivesgaard (ORCID: https://orcid.org/0000-0001-6336-9890)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Gerda Elisabeth Villadsen (ORCID: https://orcid.org/0000-0002-2757-929X)
- Lotte Bonde Bertelsen (ORCID: https://orcid.org/0000-0002-2491-3184)
- Henning Grønbæk (ORCID: https://orcid.org/0000-0001-8998-7910)
- Nina Christensen (ORCID: https://orcid.org/0000-0002-0533-5710)
- Margit Kristensen (ORCID: https://orcid.org/0000-0002-9667-2789)
- Malene Aastrup (ORCID: https://orcid.org/0009-0005-0728-3167)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4651
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00