Multi-center test-retest repeatability and reproducibility of in-vivo renal diffusion MRI measurements: preliminary findings
Motivation: As part of multi-parametric renal MRI, diffusion-weighted imaging (DWI) is a promising technique for the characterization of renal pathologies, however reliability of diffusion parameters is often hindered by lack of multi-center standardization. Goal(s): To assess repeatability and reproducibility of DWI parameters. Approach: 32 healthy volunteers were scanned in two sites using 3T MRI systems to assess kidney diffusion metrics (D,D*,F and ADC). Subjects were scanned twice on the same day for repeatability and after 7-14 days for reproducibility. Results: All diffusion metrics were consistent across scans with D, D* and ADC showing excellent repeatability and reproducibility. Impact: This study supports the reliability of diffusion-weighted imaging (DWI) in multi-center studies and demonstrates excellent repeatability and reproducibility of diffusion parameters.
Authors
- Anika Strittmatter (ORCID: https://orcid.org/0000-0002-6184-8481)
- Matias Trillini (ORCID: https://orcid.org/0000-0003-1859-1729)
- Lucian Itu (ORCID: https://orcid.org/0000-0002-2205-497X)
- Rebeca Echeverría‐Chasco (ORCID: https://orcid.org/0000-0003-0199-2593)
- María A. Fernández‐Seara (ORCID: https://orcid.org/0000-0001-8536-6295)
- Steffen Ringgaard (ORCID: https://orcid.org/0000-0001-5353-7379)
- Anna Caroli (ORCID: https://orcid.org/0000-0002-4130-4663)
- Michela Bozzetto (ORCID: https://orcid.org/0000-0002-2045-5550)
- Susan Francis (ORCID: https://orcid.org/0000-0003-0903-7507)
- Nuria Garcı́a-Fernández (ORCID: https://orcid.org/0000-0003-1082-0806)
- Anish Raj (ORCID: https://orcid.org/0000-0003-0036-0228)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- Verónica Aramendía‐Vidaurreta (ORCID: https://orcid.org/0000-0001-9834-2866)
- Niels Henrik Buus (ORCID: https://orcid.org/0000-0001-7972-8181)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Larisa Micu
- Leyre García-Ruiz (ORCID: https://orcid.org/0000-0002-2019-2885)
- Giulia Villa (ORCID: https://orcid.org/0000-0003-1120-9638)
- Paolo Brambilla (ORCID: https://orcid.org/0000-0002-6809-1178)
- Malene Aastrup (ORCID: https://orcid.org/0009-0005-0728-3167)
- Siria Pasini (ORCID: https://orcid.org/0009-0009-6879-3805)
- José María Gutierrez
- Frank G. Zoellner
- Ioana Urdea
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0764
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00