Advanced Multiparametric and [19F] MRI for Non-Invasive Assessment of Diet-Induced Liver Disease Progression in MAFLD and ALD

Motivation: This is motivated by the need for non-invasive, reliable diagnostic tools to effectively monitor and evaluate the progression of MAFLD and ALD, conditions that are escalating globally and can lead to HCC. Goal(s): The study aims to advance non-invasive diagnostic tools for tracking liver disease progression. Approach: We employed a 6-month dietary intervention in mice, using multiparametric MRI and [19F] MRI to assess liver disease progression through detailed imaging and voxel-wise analysis. Results: The comparison of 2 different analysis showed the importance of voxel-wise analysis. Compared to an average analysis of a heterogeneous liver the voxel-wise analysis is in clear detail. Impact: This study demonstrates the potential of multiparametric and [19F] MRI with PFC for non-invasive, quantitative analysis of diet-induced liver disease, revealing detailed insights into liver inflammation, fibrosis, and disease heterogeneity. This approach could inform targeted therapies and enhance translational relevance.