Quantification of the Proton Density Fat Fraction and Iron Content: A Comparative Study Between 3.0 T and 5.0 T MRI

Motivation: With the increasing availability of 5.0 T scanners, the feasibility of fat content and iron burden needs to be reevaluated at 5.0 T. Goal(s): To determine the accuracy and consistency of the PDFF and R2* in the liver, pancreas, kidney, and paraspinal muscle across different magnetic strengths and MR scanners. Approach: 127 participants underwent 3.0 T MRI 1 (uMR 780), 3.0 T MRI 2 (uMR 880), and 5.0 T MRI (uMR Jupiter). Results: The high spatial resolution of 5.0 T MRI improves the quantification accuracy of PDFF and R2* in abdominal multi-organs. Impact: Due to high interfield agreement of the PDFF and R2* with 3.0 T, 5.0 T could be used as a reliable noninvasive biomarker for quantifying fat and iron contents.