Fluid-suppressed APTw and NOEw MRI as Protein-Related Biomarkers for Differentiating IDH Status in Gliomas
Motivation: Noninvasive identification of IDH status in gliomas is crucial for clinical management but remains challenging. Goal(s): To evaluate APT-weighted and NOE-weighted MRI as biomarkers for distinguishing gliomas with IDH mutations. Approach: Application of APT-weighted and NOE-weighted MRI techniques to analyze in vivo protein-related markers in 34 glioma patients on a 3T MR scanner. Results: Significant differences in fluid-suppressed APT-weighted signals allowed for effective differentiation between gliomas with and without IDH mutations. Impact: The results demonstrated the potential of fluid-suppressed APT-weighted MRI as a noninvasive method to improve diagnostic precision in predicting IDH status and optimize clinical management of gliomas.
Authors
- Stéphane Lehéricy (ORCID: https://orcid.org/0000-0002-5802-3518)
- Moritz Zaiß (ORCID: https://orcid.org/0000-0001-9780-3616)
- Francesca Branzoli (ORCID: https://orcid.org/0000-0001-9792-0492)
- Marc Sanson (ORCID: https://orcid.org/0000-0002-1813-8476)
- Lucia Nichelli (ORCID: https://orcid.org/0009-0006-0934-5365)
- Stefano Casagranda (ORCID: https://orcid.org/0000-0002-8705-9464)
- Ottavia Dipasquale (ORCID: https://orcid.org/0000-0002-2867-8222)
- Bertrand Mathon (ORCID: https://orcid.org/0000-0002-9182-5846)
- Capucine Cadin
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1361
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00