Regional Quantification of Metabolic Liver Function Using Hyperpolarized [1-13C] Pyruvate MRI
Motivation: To prevent post-hepatectomy liver failure (PHLF) it is essential to assess liver function in the future liver remnant prior to surgery, currently volumetric measurement is used as a surrogate for liver function. Goal(s): We aimed to investigate if regional metabolic liver function could be assessed non-invasively. Approach: We used hyperpolarized [1-13C] pyruvate MRI to quantify regional metabolic changes following partial portal vein ligation in pigs. Results: Results demonstrated higher pyruvate to lactate in the future liver remnant compared to the deportalized liver (P=0.002). Impact: Hyperpolarized MRI can quantify regional metabolic liver function and may be utilized to assess liver function preoperatively to predict patients in risk of PHLF.
Authors
- Nikolaj Bøgh (ORCID: https://orcid.org/0000-0002-0321-3269)
- Uffe Kjærgaard (ORCID: https://orcid.org/0000-0002-9188-2162)
- Frank Viborg Mortensen (ORCID: https://orcid.org/0000-0001-7580-8037)
- Daniel B. Vigneron (ORCID: https://orcid.org/0000-0001-5795-8699)
- Kim Sivesgaard (ORCID: https://orcid.org/0000-0001-6336-9890)
- Michael A. Ohliger (ORCID: https://orcid.org/0000-0001-6878-8189)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Lotte Bonde Bertelsen (ORCID: https://orcid.org/0000-0002-2491-3184)
- Andrea Lund (ORCID: https://orcid.org/0000-0002-7016-097X)
- Margit Kristensen (ORCID: https://orcid.org/0000-0002-9667-2789)
- Malene Aastrup (ORCID: https://orcid.org/0009-0005-0728-3167)
- Mohsen Redda (ORCID: https://orcid.org/0009-0007-8972-4820)
- Aage Olsen Alstrup
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1736
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00