Liver Tumor Differentiation Enhanced by Adding Hepatobiliary Phase MR Fingerprinting: A Multi-parametric Diagnostic Approach
Motivation: Liver tumor differentiation by MRI has largely relied on T1 mapping with limited studies incorporating multiple quantitative parameters such as T2. Expanding MR Fingerprinting (MRF) to a multi-parametric approach may improve diagnostic accuracy. Goal(s): To evaluate the effectiveness of adding MRF during the hepatobiliary phase of gadoxetic acid-enhanced MRI for improved liver tumor differentiation using a multi-parametric approach. Approach: A 9-echo MRF sequence measured T1, T2, T2*, and FF pre-contrast and MRF-derived T1 reduction rate post-contrast. Results: MRF-derived T1 reduction rate addition significantly improved benign/malignant differentiation, achieving a multivariate AUC of 0.89. Impact: Incorporating a multi-parametric approach with MRF during the hepatobiliary phase of gadoxetic acid-enhanced MRI improves diagnostic accuracy in liver tumor differentiation, potentially reducing reliance on dynamic phases and enhancing non-invasive diagnostic capabilities in clinical liver assessments.
Authors
- Claudia Prieto (ORCID: https://orcid.org/0000-0003-4602-2523)
- Kenichi Ikejima (ORCID: https://orcid.org/0000-0002-2657-0840)
- Yuichi Morita (ORCID: https://orcid.org/0000-0002-7329-7496)
- Wataru Uchida
- Gastão Cruz (ORCID: https://orcid.org/0000-0002-7397-9104)
- Takashi Arai (ORCID: https://orcid.org/0000-0001-7182-3176)
- Ryohei Kuwatsuru (ORCID: https://orcid.org/0000-0003-1960-6400)
- Shohei Fujita (ORCID: https://orcid.org/0000-0003-4276-6226)
- Yutaka Ikenouchi
- Katsuhiro Sano (ORCID: https://orcid.org/0000-0002-8388-3827)
- Yuki Fukumura (ORCID: https://orcid.org/0000-0002-7702-6634)
- Koji Kamagata (ORCID: https://orcid.org/0000-0001-5028-218X)
- A Suzuki (ORCID: https://orcid.org/0000-0002-4457-3260)
- Carlos Velasco (ORCID: https://orcid.org/0000-0002-1226-3436)
- Hideo Kawasaki (ORCID: https://orcid.org/0000-0002-1942-9363)
- Shigeki Aoki (ORCID: https://orcid.org/0000-0003-2821-0651)
- Akio Saiura
- René Botnar (ORCID: https://orcid.org/0000-0002-9447-4367)
- Diego Pedraza
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0775
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00