The default mode network is causally involved in memory retrieval and network integration plays a key role in this process

Motivation: Network integration is crucial for learning and memory, but whether the integration of default mode network (DMN) supports memory processes remains unclear. Goal(s): This study aims to assess if modulating DMN integration causally affects memory precess. Approach: In C57 mice, we chemogenetically suppressed the DMN hub, the dorsal anterior cingulate cortex (dACC), and analyzed DMN architecture using resting-state fMRI, alongside memory behavior tests. Results: Inhibition of dACC disrupted DMN integration and impaired memory recall. The altered DMN integration correlated with behavioral deficits, suggesting its critical role in memory process. Impact: Our results show that DMN plays a causal role in memory processes, emphasizing the importance of network integration for memory. These findings enhance our understanding of DMN's involvement in higher-order cognition and offer potential measurement methods for various brain disorders.