CVR Transfer Functional Analysis and multi-PLD pCASL MRI to examine vascular dynamics during subacute stroke recovery

Motivation: The subacute phase of stroke recovery is crucial for rehabilitation, but the vascular dynamics of repair and angiogenesis remain poorly understood Goal(s): To examine the capability of physiological MRI to delineate the vascular dynamics during subacute stroke recovery Approach: CVR transfer function analysis (TFA) and 3D-pCASL (2200 and 2800 msec post-labeling delays) were collected from a subacute stroke patient longitudinally. Results: The TFA results show that the lesion and surrounding areas stabilize during recovery, with the vascular steal phenomenon occurring in the affected hemisphere. The multi-delay pCASL technique effectively shows a collateral flow that supports recovery and angiogenesis. Impact: Given that stroke has a vascular etiology, characterizing the vascular remodeling and associated dynamics, especially during the subacute phase is crucial to developing effective stroke rehabilitation strategies. Advanced physiological MRI techniques designed for this purpose can significantly influence clinical practice.