Longitudinal assessment of changes in the BBB water permeability in a mouse model of Huntington's Disease using multi-TE ASL MRI
Motivation: Huntington's disease (HD) lacks disease-modifying treatments. Investigating blood-brain barrier (BBB) water permeability may reveal early biomarkers of disease progression. Goal(s): The study aims to assess BBB water permeability in the zQ175DN HD mouse model by analyzing longitudinal changes in water exchange time using multi-TE ASL MRI. Approach: Analysis was performed in control and HD mice at 3, 6, and 9 months of age, focusing on water exchange time in striatum and cortical regions. Results: Reduced water exchange time was observed in the somatosensory and cingulate cortex in HD mice, suggesting increased BBB permeability at 9 months of age. Impact: This study indicates that using the non-invasive multi-TE ASL MRI technique, alterations in water exchange time can be detected in the zQ175DN mouse model of Huntington's Disease at 9 months of age.
Authors
- Dorian Pustina (ORCID: https://orcid.org/0000-0002-2834-7220)
- Marleen Verhoye (ORCID: https://orcid.org/0000-0002-6267-0611)
- Yolanda Ohene (ORCID: https://orcid.org/0000-0002-0213-6302)
- Tamara Vasilkovska (ORCID: https://orcid.org/0000-0001-7611-3966)
- Roger Cachope (ORCID: https://orcid.org/0000-0002-7217-0119)
- Johan Van Audekerke (ORCID: https://orcid.org/0000-0001-5944-4640)
- Daniele Bertoglio (ORCID: https://orcid.org/0000-0003-4205-5432)
- Jack A. Wells (ORCID: https://orcid.org/0000-0002-4171-3539)
- Mohit H. Adhikari (ORCID: https://orcid.org/0000-0002-3404-8307)
- Joëlle van Rijswijk (ORCID: https://orcid.org/0000-0001-6971-7358)
- Haiying Tang
- Ignace Van Spilbeeck
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1237
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00