The Targeted 1H MRS of Methylmalonic Acid and Lactate In Vivo
Motivation: Methylmalonic acidemia is an extremely harmful organic acidemia causing multi-system damage mainly in the central nervous system. Goal(s): To selectively probe the 1H MR signals of methylmalonic acid and lactate (Lac) in vivo in the brain of methylmalonic acidemia (MMA) patients. Approach: The optimal J-editing 1H MRS approach was used to probe the MMA and Lac signals in vivo. Results: The methylmalonic acid and lactate 1H MR signals were selectively probed in a phantom and 8 MMA patients, confirming their correlation with urine and blood concentration levels. Impact: We successfully detected methylmalonic acid and Lac signals in MMA patients, providing crucial support for exploring MMA metabolic pathways in vivo.
Authors
- Tao Gong (ORCID: https://orcid.org/0000-0002-9866-9911)
- Guangbin Wang (ORCID: https://orcid.org/0000-0001-7410-5540)
- Jiaxiang Xin
- Min Zhuo (ORCID: https://orcid.org/0000-0001-9062-3241)
- Xiaojing Xing (ORCID: https://orcid.org/0000-0002-4071-7482)
- Yan Yun
- Yufan Chen
- Yuxin Li (ORCID: https://orcid.org/0000-0003-3362-1201)
- Fei Liu (ORCID: https://orcid.org/0000-0003-0064-7827)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-3887-5323)
- Yao Zou (ORCID: https://orcid.org/0000-0003-1418-7331)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2257
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00