Brain Structural and Functional Connectivity Alterations in Heart Failure Patients

Motivation: To understand the specific brain structural alterations and functional connectivity changes in heart failure (HF) patients, influenced by HF etiology, which contribute to cognitive deficits. Goal(s): This study aims to delineate brain changes in HF patients compared to controls, focusing on the impact of HF etiology on neurological manifestations. Approach: A prospective study of 35 HF patients and 12 controls underwent cardiovascular exams, cognitive assessments, and brain MRI scans, utilizing VBM and functional connectivity analysis. Results: HF patients showed atrophy in brain regions linked to memory and executive functions, enhanced functional connectivity, and reduced cortical thickness, indicating structural and functional brain alterations. Impact: This study provides insights into the neurological consequences of heart failure, potentially guiding the development of interventions for associated cognitive decline.