Feasibility of Ultra- Low-Field MRI for Measurement of Regional Infant Brain Volumes in Structures Associated with Anaemia
Motivation: The extent to which ultra- low-field MRI can detect the impact of antenatal maternal anaemia on child brain structure is unknown, particularly in infants. Goal(s): To assess the comparability of ultra-low (64mT) and high-field (3T) volumes in infants from the Khula South Africa birth cohort for brain regions associated with maternal anaemia. Approach: Correlations and concordance coefficients were used to investigate associations between ultra-low and high-field infant brain volumes for the corpus callosum, caudate, and putamen. Results: Findings demonstrated a strong linear association and a high degree of concordance between ultra-low and high-field regional brain volumes in infants between 3-24 months of age. Impact: This study demonstrates high comparability between ultra- low-field (64mT) and high-field (3T) volumes for brain regions implicated in antenatal maternal anaemia. Findings validate the use of the Hyperfine scanner for paediatric neuroimaging work on anaemia across low- and middle-income countries.
Authors
- Catherine J. Wedderburn (ORCID: https://orcid.org/0000-0002-4887-1644)
- Niall Bourke (ORCID: https://orcid.org/0000-0001-6478-1430)
- Michal R. Zieff (ORCID: https://orcid.org/0000-0001-9352-9947)
- Daniel A. Alexander (ORCID: https://orcid.org/0000-0003-3831-7479)
- Carly Bennallick
- Chiara Casella (ORCID: https://orcid.org/0000-0002-0292-3330)
- Jonathan O’Muircheartaigh (ORCID: https://orcid.org/0000-0002-8033-6959)
- Simone Williams
- Dan Joseph Stein (ORCID: https://orcid.org/0000-0001-7218-7810)
- Jessica E. Ringshaw (ORCID: https://orcid.org/0000-0001-6885-8351)
- Kirsten A. Donald (ORCID: https://orcid.org/0000-0002-0276-9660)
- Marlie Miles (ORCID: https://orcid.org/0009-0004-7526-8885)
- Steven Williams (ORCID: https://orcid.org/0000-0003-0565-9624)
- Derek A. Jones (ORCID: https://orcid.org/0000-0003-3082-6527)
- Layla Bradford
- Donna Herr (ORCID: https://orcid.org/0000-0002-7721-9129)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0851
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00