129Xe multi-b Diffusion Weighted Imaging of lung with 3D Golden-Angle Radial Sampling and Keyhole Reconstruction

Motivation: Conventional 129Xe GRE DWI requires long acquisition time and has large slice thickness, limiting its applications in patients with pulmonary diseases. Goal(s): To develop a method to accelerate 129Xe multi-b DWI and obtain isotropic DW images, enabling assessment of morphology changes caused by lung diseases. Approach: We combined 3D golden-angle radial sampling with keyhole reconstruction (GRSK) to conduct pulmonary 129Xe DWI, and applied it in patients with emphysema. Results: By using the proposed method, 4 b-values pulmonary DW images with a spatial resolution of 5×5×5 mm3 could be acquired within 11.4 s. Impact: 3D GRSK method was used to accelerate multi-b 129Xe DWI, obtaining 4 b-values pulmonary DW images with isotropic resolution of 5 mm within 11.4 s, and was applied in patients with emphysema.