Reproducibility of MRI-based PDFF Quantification of Liver, Pancreas, Kidney, and Paraspinal Muscle on MRI at 5 T and 3 T in NAFLD subjects

Motivation: Since early NAFLD is reversible, early detection and intervention, progression to irreversible liver damage, and other long-term NAFLD complications should be indicated. Goal(s): Before MRI-based PDFF is performed at 5.0 T, the agreement between the PDFF measurements in the liver, pancreas, kidney, and paraspinal muscle should be determined at 3.0 T and 5.0 T. Approach: MRI-based PDFF were obtained from the liver, pancreas, kidney, and paraspinal muscle in 120 healthy and NAFLD subjects on 3.0 T MRI 1, 3.0 T MRI 2, 5.0 T MRI. Results: PDFF showed high reproducibility for all organs within the same field and across-field strength in NAFLD subjects. Impact: 5.0 T is a reliable noninvasive biomarker of PDFF measurements in abdominal organs and may be helpful for early screening of NAFLD diseases.