Glutamate modulation in the dACC during inhibitory control with food-cues using 1H fMRS predicts BMI following weight loss

Motivation: The neurobiological mechanisms underlying poor weight loss maintenance are poorly understood. Goal(s): Our goal was to study differences in glutamate modulation across different inhibitory motor control task conditions following completion of a clinical weight loss intervention. Approach: 1H fMRS was conducted on participants following a clinical weight loss intervention. Results: The use of food cues as stimuli influenced glutamate modulation during inhibitory control and correlated with long-term BMI. Impact: With further research, this evidence of food-cue specific differences in glutamate modulation predicting long-term BMI may fuel better behavioral treatment plans to support more successful long-term weight loss maintenance in individuals with obesity.