129Xe MRI is sensitive to pulmonary hemodynamics in systemic sclerosis patients with suspected pulmonary arterial hypertension
Motivation: Early detection of pulmonary arterial hypertension (PAH) can facilitate early treatment, improving outcomes. Goal(s): To use 1H and 129Xe MR, including 129Xe dissolved phase MRI/MRS, to identify markers of PAH in patients with systemic sclerosis (SSc). Approach: Patients with SSc and suspected PAH were recruited for 1.5T 1H and 129Xe MRI, and where possible, same day right heart catheterisation and pulmonary function tests. Results: 13 datasets were analysed. The oscillation amplitude of 129Xe signal dissolved in the red blood cells correlated positively with mean pulmonary artery pressure and is a promising marker of pulmonary hypertension in this population. Impact: 129Xe red blood cell oscillation amplitude is a promising, non-invasive MRI marker of elevated pulmonary arterial pressure in patients with systemic sclerosis. 1H and 129Xe MRI provide clinically relevant and complementary information on pulmonary function in this population.
Authors
- Jim M. Wild (ORCID: https://orcid.org/0000-0002-7246-8660)
- Laurie Smith (ORCID: https://orcid.org/0000-0002-5769-423X)
- Alexander Rothman (ORCID: https://orcid.org/0000-0002-7847-4500)
- David Gerard Kiely (ORCID: https://orcid.org/0000-0003-0184-6502)
- Guilhem Collier (ORCID: https://orcid.org/0000-0002-1874-4775)
- Graham Norquay (ORCID: https://orcid.org/0000-0002-4108-9035)
- Neil J. Stewart (ORCID: https://orcid.org/0000-0001-8358-394X)
- Robin Condliffe (ORCID: https://orcid.org/0000-0002-3492-4143)
- Laura Saunders (ORCID: https://orcid.org/0000-0002-1080-9861)
- A. A. Roger Thompson (ORCID: https://orcid.org/0000-0002-0717-4551)
- Paul Hughes (ORCID: https://orcid.org/0000-0002-7979-5840)
- Felicity Hitchcock
- Alberto Biancardi (ORCID: https://orcid.org/0009-0000-2765-0773)
- Helen Marshall (ORCID: https://orcid.org/0000-0002-7425-1449)
- Jemima Pilgrim-Morris (ORCID: https://orcid.org/0009-0000-5343-2446)
- Ian Smith
- Andy Swift
- Scarlett Strikland
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4638
- Primary Topic
- Medical Imaging and Pathology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00