Choroid Plexus Enlargement related to tau deposition in progressive supranuclear palsy

Motivation: Choroid plexus (CP) enlargement is linked to impaired protein clearance in neurodegenerative disorders, but its role in progressive supranuclear palsy (PSP) remains unclear. Goal(s): To investigate CP volume changes and their relationship with tau deposition in PSP. Approach: A total of 204 participants (92 PSP, 78 PD, 34 HC) underwent MRI; 63 PSP patients also had 18F-Florzolotau PET. CP volumes were compared among groups, and their association with PET-derived tau standardized uptake value ratios (SUVRs) was assessed. Results: PSP patients had larger CP volumes compared to PD and HC groups. In PSP, CP volume was positively correlated with mean SUVRs in the putamen. Impact: CP volume expansion may serve as a promising imaging biomarker of tau accumulation in PSP patients and could potentially be used to differentiate PSP from PD.