First implementation of fast 1H 3D-FID-MRSI on the rodent brain at 9.4T for metabolite mapping

Motivation: Preclinical 2D 1H-FID-MRSI has offered great and reproducible metabolite maps on the rat brain. The technique can be extended for whole-brain acquisition for richer information. Goal(s): Implement and test the feasibility of 3D and multislice 1H-FID-MRSI for rat brain metabolite mapping. Approach: Using optimized compressed sensing schemes to accelerate 3D and multislice acquisition, for volumetric acquisition in the rat brain. Results: Both methodologies have produced great through-plane coverage and concentration estimates are in line with 2D FID-MRSI measurements. Impact: 3D and multislice 1H-FID-MRSI can offer greater insight in the rat brain metabolism, enabling finer description of neurodegenerative diseases within preclinical models, such as the bile duct ligation rat model for hepatic encephalopathy.