Use of Multi-Modal Non-Contrast MRI to Predict Functional Outcomes after Stroke: a study using DP-pCASL, DTI, NODDI, and MAP MRI

Motivation: There is a limited understanding of how kw variability after acute ischemic stroke (AIS) impacts recovery. Goal(s): This study aims to determine the relationship between kw and functional outcomes measured by the modified Rankin scale (mRS) in the AIS population. Approach: 22 AIS patients enrolled from 1/2022 to 4/2024 underwent DP-pCASL, DTI, NODDI and MAP imaging on a 3.0-Tesla scanner. Results: Multivariable linear regression identified lower kw, higher time to MRI and larger stroke volume as predictive of higher mRS. Higher CBF, QMSD, and RTAP, and lower SD RTAP, RTPP, and NG were most predictive of kw. Impact: This study demonstrates kw's potential as a functional outcome predictor in patients with AIS.CBF, QMSD, and RTAP, SD RTAP and NG were predictors of kw. Larger studies are needed tounderstand these relationships and kw's usefulness in clinic settings.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/2525
Primary Topic
Advanced MRI Techniques and Applications
Type
article
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article

Use of Multi-Modal Non-Contrast MRI to Predict Functional Outcomes after Stroke: a study using DP-pCASL, DTI, NODDI, and MAP MRI

Adam E. Flanders, Christian Raimondo, Stavropoula I. Tjoumakaris, Nikolaos Mouchtouris et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced MRI Techniques and Applications
article

Use of Multi-Modal Non-Contrast MRI to Predict Functional Outcomes after Stroke: a study using DP-pCASL, DTI, NODDI, and MAP MRI

Adam E. Flanders, Christian Raimondo, Stavropoula I. Tjoumakaris, Nikolaos Mouchtouris, Mahdi Alizadeh, Robert H. Rosenwasser, Joanna M. Roy, Michael Reid Gooch, Keenan Piper, Julia A. Diamandi
article en

Abstract

Motivation: There is a limited understanding of how kw variability after acute ischemic stroke (AIS) impacts recovery. Goal(s): This study aims to determine the relationship between kw and functional outcomes measured by the modified Rankin scale (mRS) in the AIS population. Approach: 22 AIS patients enrolled from 1/2022 to 4/2024 underwent DP-pCASL, DTI, NODDI and MAP imaging on a 3.0-Tesla scanner. Results: Multivariable linear regression identified lower kw, higher time to MRI and larger stroke volume as predictive of higher mRS. Higher CBF, QMSD, and RTAP, and lower SD RTAP, RTPP, and NG were most predictive of kw. Impact: This study demonstrates kw's potential as a functional outcome predictor in patients with AIS.CBF, QMSD, and RTAP, SD RTAP and NG were predictors of kw. Larger studies are needed tounderstand these relationships and kw's usefulness in clinic settings.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 65%
Advanced MRI Techniques and Applications
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