Accelerated T1 and T*2 Mapping with Scan Specific Unsupervised Networks and Subspace Modeling

Motivation: To provide high fidelity in multi-parametric quantitative MRI reconstruction by integrating subspace modeling with phase priors. Goal(s): We propose Sub-MAPLE, designed as a self-supervised, model-based approach for multi-parametric mapping, capable of simultaneously estimating T1, T*2, frequency, and proton density maps. Approach: The proposed framework replaces the signal model by subspace modeling integrated with phase priors, enhancing reconstruction performance and leading to improved multi-parametric mapping. Results: The proposed method demonstrates superior performance in both multi-contrast reconstruction and multi-parametric mapping compared to state-of-the-art self-supervised AI-based and conventional parallel imaging techniques. Impact: Sub-MAPLE estimates T1, T*2, frequency, and proton density at high acceleration rates, outperforming the state-of-the-art Joint MAPLE and conventional methods. It incorporates subspace modeling with phase priors, enabling high accuracy mapping from 15-fold accelerated acquisitions.