Measurement of tryptophan relaxation times in human brain using downfield 1H MRS at 7 T
Motivation: Determine the tryptophan (TRP) relaxation rates from human brain 1H downfield spectrum in vivo. Goal(s): To estimate the T1 and T2 of TRP in healthy human brains at 7 T Approach: We determined TRP relaxation times using a spectrally- and slice-selective downfield MRS sequence. Results: The mean T1 and T2 estimates of TRP from in vivo human brain were 74.5±12.5ms (n=6) and 19.3±3.5ms (n=8), respectively. Impact: Reliable in vivo brain TRP relaxation measures in normal subjects could help establish reference values and also aid in utilizing it as a novel non-invasive in vivo biomarker for various aging-related and neuropsychiatric disorders.
Authors
- Sophia Swago (ORCID: https://orcid.org/0000-0001-8334-4746)
- Ravi Prakash Reddy Nanga (ORCID: https://orcid.org/0000-0002-3644-5656)
- Ravinder Reddy (ORCID: https://orcid.org/0000-0003-4580-2392)
- Walter R T Witschey (ORCID: https://orcid.org/0000-0003-1669-2120)
- Mark Elliott (ORCID: https://orcid.org/0000-0002-5281-7245)
- Neil Wilson (ORCID: https://orcid.org/0009-0002-7766-2929)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1506
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00