Optimized 3D T2-prep MRF for accurate T1 and T2 maps, with B0 and B1 field inhomogeneity correction and motion correction

Motivation: MR Fingerprinting (MRF) is a prominent quantitative MRI technique known for its rapid and high-resolution data acquisition; however, it often demonstrates reduced accuracy in T2 quantification relative to T1. Goal(s): To enhance T2 robustness to B0 and B1 inhomogeneities and mitigate motion artifacts. Approach: Combined with B0, B1, and motion estimation, T2 preparation modules were integrated into a previously developed 3D FISP-MRF sequence to enhance T2 encoding, with Cramér-Rao Lower Bound optimization applied to both T2prep and flip angle (FA) parameters for further optimization. Results: Phantom studies revealed enhanced T2 accuracy, while in-vivo studies demonstrated improved resilience to motion artifacts and B0/B1 inhomogeneities. Impact: The improved T2 quantification accuracy and robustness to motion artifacts and field inhomogeneities could significantly enhance the reliability of MRF in both clinical and research settings.