Brain Volume Reduction in Thrombotic Thrombocytopenic Purpura: A Quantitative MRI Study in Patients in Remission

Motivation: Thrombotic thrombocytopenic purpura (TTP) is a severe disorder that can cause acute neurological symptoms. Although many patients enter remission, evidence suggests potential long-term neurological consequences. Goal(s): To explore brain volume alterations in TTP patients in remission to assess possible chronic impacts. Approach: Sixteen TTP patients in remission were evaluated with magnetic resonance imaging (MRI) and compared to an age- and sex-matched control group. Images were analyzed using FreeSurfer software. Results: A significant 20.39% reduction in total brain volume was observed, indicating potential structural alterations associated with TTP. Impact: These findings suggest that TTP may cause lasting structural brain changes even after the acute phase, potentially contributing to chronic neurological deficits. This study highlights the importance of continuous monitoring of TTP patients in remission.