Comparison of CE-MRI, Non-contrast-enhanced MRV and Black Blood Imaging in the diagnosis of Cerebral Vein Thrombosis：A Meta-Analysis

Motivation: The early diagnosis of cerebral venous thrombosis (CVT), a rare disease with poor prognosis, currently poses a clinical challenge. Goal(s): To assess the accuracy of Black Blood Imaging (BBI), Contrast-enhanced MRI (CE-MRI) and Noncontrast-enhanced MR venography (NCE-MRV) in diagnosing CVT. Approach: A comprehensive review of literature from January 2013 to August 2024 was conducted and compare the diagnostic performance of BBI, CE-MRI and NCE-MRV. P< .05 indicates significant difference. Results: The area under the curve (AUC) for BBI was 1.00, significantly outperforming CE-MRI and NCE-MRV (P < .005). The AUC for CE-MRI achieved comparable results to NCE-MRV (0.93 vs. 0.95; P = 0.08). Impact: BBI exhibits the utmost accuracy in diagnosing CVT when compared to NCE-MRV and CE-MRI, poised to become a frontline diagnostic tool. While NCE-MRV surpasses CE-MRI in CVT detection sensitivity, it lags slightly in excluding non-CVT cases.