Multiparametric MRI assessment of neuronal vascular unit destruction in rats after cerebral ischemia reperfusion injury
Motivation: Exploring an MRI assessment method that offers a noninvasive way to monitor NVU damage after IS. Goal(s): To assess neurovascular unit (NVU) damage in cerebral ischemia reperfusion injury (CIRI) rats to provide a visual basis for clinical diagnosis and treatment of CIRI. Approach: Establishment of CIRI rats, multiparametric MRI combined with various histological techniques. Results: CIRI leads to NVU injury, blood-brain-barrier (BBB) disruption, and exacerbation of brain damage in rats. Multiparametric MRI combined with various histopathological techniques effectively assesses NVU injury after CIRI. Impact: The pathological hallmarks of acute ischemic stroke (AIS) are NVU damage and BBB destruction, and its clinical treatment has shifted from single neuron protection to NVU protection, which has become a new target for studying neuronal damage and protection mechanisms.
Authors
- Zhenlin Li (ORCID: https://orcid.org/0000-0002-3706-4505)
- Peng Wu (ORCID: https://orcid.org/0000-0001-7140-5388)
- Xizhen Wang (ORCID: https://orcid.org/0000-0003-0993-1170)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-8329-1920)
- Yan Qin (ORCID: https://orcid.org/0000-0002-2958-8122)
- S T Hu (ORCID: https://orcid.org/0000-0001-6831-2105)
- Xiaoli Wang (ORCID: https://orcid.org/0000-0002-9388-0734)
- Xiaofeng Zhang (ORCID: https://orcid.org/0000-0003-2738-3286)
- Yongjun Cheng (ORCID: https://orcid.org/0009-0008-2886-2362)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2520
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00