Monitoring treatment-induced nephropathy using multiparametric functional MRI in patients undergoing radionuclide therapy – a pilot study
Motivation: Radiation-induced nephropathy is a therapy-limiting risk factor in patients undergoing oncologic treatment. Goal(s): Our goal was to evaluate multiparametric MRI for diagnostic of functional and structural changes in kidneys with risk of developing radiation-induced nephropathy. Approach: We examined 23 patients undergoing radionuclide therapy and 10 healthy volunteers with a multiparametric MRI protocol including ASL, DWI, BOLD, T1 & T2 mapping and volumetry. Results: Several correlations could be found between MR parameters and clinical kidney function diagnostics as well as with radiation dose per kidney. Impact: Multiparametric renal MRI could serve as an additional non-invasive diagnostic tool to detect and monitor radiation-induced nephropathy during cancer treatment.
Authors
- Helmut Dittmann (ORCID: https://orcid.org/0000-0001-6840-5571)
- Petros Martirosian (ORCID: https://orcid.org/0000-0001-8383-0883)
- Konstantin Nikolaou (ORCID: https://orcid.org/0000-0003-2668-7325)
- Thomas Küstner
- Christian la Fougère (ORCID: https://orcid.org/0000-0001-7519-0417)
- Fritz Schick (ORCID: https://orcid.org/0000-0002-4231-3406)
- Brigitte Gückel (ORCID: https://orcid.org/0000-0001-7761-7592)
- Cecilia Liang (ORCID: https://orcid.org/0000-0002-6937-1681)
- Ferdinand Seith (ORCID: https://orcid.org/0000-0002-9696-2954)
- Nils Florian Trautwein (ORCID: https://orcid.org/0000-0003-3397-6299)
- Isabelle Loster
- Ghoul Aya
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2434
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00