State-related alterations of anterior cingulate cortex subregional connectivity in major depressive disorder

Motivation: The anterior cingulate cortex (ACC) subregional functional connectivity alterations from acute to remitted status of major depressive disorder (MDD) remained unclear. Goal(s): To explore the status-related alterations (acute vs. remitted status) in functional connectivity of ACC subregional networks in patients with MDD. Approach: We performed a longitudinal study to investigated ACC subregional functional connectivity alteration from acute to remitted status, and their correlations with clinical symptoms changes in MDD patients. Results: We discovered perigenual/subgenual ACC-based hypoconnectivity and cadual ACC-based hyperconnectivity with default mode network related to the remission period of MDD, and decreased ACC subregional connectivity alterations were correlated with depression symptom improvement. Impact: Our findings highlight the status-related alterations in rsFC of ACC subregional networks in MDD, which can help to understand the neurobiological mechanisms of depression at various stages and provide theoretical guidance for clinical management.