Dynamic contrast-enhanced gastric MRI features for preoperative prediction of microsatellite instability status in gastric cancer

Motivation: Microsatellite instability (MSI) status offers a predictive value in response to adjuvant chemotherapy and overall prognosis in gastric cancer (GC). Extra-dimensional volumetric interpolated breath-hold examination (XD-VIBE) offers high temporal and spatial resolution while allowing free breathing. Goal(s): To evaluate the relationship between XD-VIBE dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters and the MSI status of GC. Approach: We evaluated the associations of quantitative DCE-MRI parameters (e.g., Ktrans, Ve, Vp, and Kep) with MSI status. Results: XD-VIBE DCE-MRI quantitative parameters allowed non-invasive assessment of MSI status of GC preoperatively and helped to optimize treatment strategies for GC. Impact: In this single-institution study, XD-VIBE DCE-MRI quantitative parameters demonstrated promise as markers of MSI status in GC. These features could provide added prognostic value and may assist in making individualized treatment decisions and positioning for biopsy.