Metabolic dysfunction-associated steatohepatitis (MASH) dampens liver fat reduction in participants after metabolic bariatric surgery
Motivation: Patients with MASH have increased inflammation and insulin resistance, however whether this translates to dampened liver fat reduction after weight loss is not known. Goal(s): Our goal was to assess if patients with MASH have altered liver fat reduction after weight loss. Approach: Baseline MASH status was determined in participants with obesity via biopsy during metabolic bariatric surgery. Liver PDFF was assessed by MRI pre-op and 12 months post-op and the changes were compared between groups. Results: Participants with MASH had dampened reduction of liver PDFF after metabolic bariatric surgery when controlling for baseline PDFF. Impact: For patients with obesity and MASH, adjuvant treatment may be needed to achieve the same total goal reduction in liver fat as patients without MASH.
Authors
- Eduardo L. Grunvald (ORCID: https://orcid.org/0000-0001-9332-7069)
- Walter C. Henderson (ORCID: https://orcid.org/0000-0001-8225-4722)
- Claude B. Sirlin (ORCID: https://orcid.org/0000-0002-6639-9072)
- Ryan C. Broderick (ORCID: https://orcid.org/0000-0002-1821-9989)
- Garth R. Jacobsen
- Anne O. Lidor (ORCID: https://orcid.org/0000-0002-9911-3114)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Yesenia Covarrubias
- Rashmi Agni (ORCID: https://orcid.org/0000-0001-7803-4647)
- Luke M. Funk (ORCID: https://orcid.org/0000-0003-4475-304X)
- Jeffrey B. Schwimmer (ORCID: https://orcid.org/0000-0001-8538-2877)
- Danielle Batakis
- Vitor F. Martins (ORCID: https://orcid.org/0000-0002-9060-1314)
- Tanya Wolfson
- David Harris (ORCID: https://orcid.org/0000-0003-4995-5126)
- Jake Weeks
- Ryan Sappenfield
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2671
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00