Sleeping Under the Looping Star: Identifying BOLD Spectral Correlates of Sleep with Silent fMRI.
Motivation: Memory consolidation, synaptic pruning, waste-clearance, immune and hormone modulation require neurovascular-sleep dynamics. We evaluate the novel, silent, Looping Star with the aim of capturing the sleep cycle without acoustic-evoked-microarousals. Goal(s): To demonstrate the spectral fidelity of silent fMRI with Looping Star, and the ability to detect low and high-frequency BOLD spectral features associated with sleep. Approach: Multi-echo Looping Star was tested in volunteers by synchronizing to their natural sleep cycle. BOLD spectral power between low(<0.1Hz) and high(>0.1Hz) frequency bands was evaluated. Results: Distinct transitions between awake, drift and sleep are noted, while replicating previously reported spectral correlates of EEG-fMRI of NREM sleep. Impact: Due to difficulty of simultaneous EEG-fMRI and the acoustic footprint, our understanding of sleep remains limited. Using the silent Looping Star we report sleep, drift and awake-brain hemodynamic activity. Signatures correlate with slow-wave and spindle activity previously reported with EEG-fMRI.
Authors
- Ana M. Sánchez (ORCID: https://orcid.org/0000-0002-8230-6059)
- Rasmus M. Birn (ORCID: https://orcid.org/0000-0003-3938-1077)
- H Douglas Morris (ORCID: https://orcid.org/0000-0002-7942-3748)
- Thomas Foo (ORCID: https://orcid.org/0000-0002-9016-1005)
- Florian Wiesinger (ORCID: https://orcid.org/0000-0002-5597-6057)
- Angeliki Pollatou (ORCID: https://orcid.org/0000-0003-0379-4187)
- Vincent B. Ho (ORCID: https://orcid.org/0000-0001-6603-8384)
- Luca Marinelli (ORCID: https://orcid.org/0000-0001-7775-5952)
- Kevin J. DeMarco
- Nastaren Abad (ORCID: https://orcid.org/0000-0002-7020-0492)
- Brice Fernandez (ORCID: https://orcid.org/0000-0002-8693-2313)
- Isabelle Heukensfeldt Jansen (ORCID: https://orcid.org/0009-0004-6490-4882)
- J. Kent Werner (ORCID: https://orcid.org/0000-0001-9858-2931)
- M. Jeong
- Afis Ajala (ORCID: https://orcid.org/0000-0002-1763-0274)
- Melanie Boly (ORCID: https://orcid.org/0000-0002-1420-4587)
- Gail Khols
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2489
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00