Intrinsic Functional Connectivity as a Moderator and Consequence of Cocaine Self-Administration in Rats

Motivation: This study investigates the effects of cocaine self-administration on functional connectivity between brain regions in rats, specifically focusing on the anterior insular and retrosplenial cortex. Goal(s): To understand how functional connectivity changes between these regions as a consequence of cocaine exposure. Approach: Using fMRI, significant changes in connectivity were observed over time, linked to escalated cocaine intake and prolonged abstinence. Results: The findings suggest that functional connectivity between the anterior insular and retrosplenial cortex not only changes as a consequence of cocaine exposure but also serves as a moderator of addiction-related behaviors, highlighting potential targets for intervention in cocaine use disorders.. Impact: This study provides new insights into how brain network connectivity is both altered by and predictive of cocaine use, suggesting new circuit-based treatment strategies.