A Study on Predicting Individual Kidney Function Using Renal Blood Flow Weighted eGFR Using Arterial Spin Labeling MRI

Motivation: Renal artery stenosis(RAS) often leads to hypertension and renal insufficiency, yet diagnosing Individual renal function accurately is challenging. Goal(s): To develop an renal blood flow(RBF) weighted estimated glomerular filtration rate (eGFR) method using arterial spin labeling MRI(ASL-MRI) for better Individual renal function assessment. Approach: 32 patients with RAS underwent ASL-MRI; RBF-weighted eGFR was calculated and compared to radionuclide GFR. Results: The RBF-weighted eGFR based on ASL-MRI had a high consistency with the GFR values of the radionuclide renal dynamic imaging, and a high diagnostic efficacy in the differential diagnosis of renal dysfunction. Impact: This novel method improves renal function assessment in RAS patients, potentially guiding clinical decisions and facilitating further research into renal disease management.