Exploring Lumbar Intervertebral Disc Degeneration via 23Na-MRI: A Clinical Study

Motivation: Intervertebral disc degeneration (IDD) significantly contributes to chronic low back pain, yet traditional imaging techniques are limited in their ability to provide quantitative assessments. Goal(s): This study aimed to evaluate the clinical applicability of 23Na-MRI in assessing sodium concentration as a biomarker for disc degeneration. Approach: 23Na signal intensities were compared with T2-weighted images and the Pfirrmann classification in 90 intervertebral discs of 30 patients. Results: 23Na-MRI demonstrated significant correlations with T2 ratios, disc thickness, and degeneration grades, proving its effectiveness for quantifying IDD progression. Impact: 23Na-MRI offers a non-invasive method to quantitatively assess intervertebral disc degeneration, complementing traditional techniques. Its strong correlation with disc degeneration indicators supports its clinical relevance, potentially improving diagnosis and treatment for patients with chronic low back pain.