Design of a dynamic Sodium (23Na) phantom to evaluate NORDIC on changes in tissue sodium concentration.

Motivation: To perform 23Na MRI to study dynamic changes in tissue sodium concentration in-vivo. Goal(s): To demonstrate the application of NOise Reduction with DIstribution Corrected (NORDIC) PCA denoising to 23Na MRI data. Approach: We propose a dynamic phantom to validate the sensitivity to assessing a spatially defined dynamic change in 23Na concentration, to mimic changes which may occur in muscle or brain functional sodium and apply NORDIC denoising to the data. Results: NORDIC was shown to reduce noise in a 23Na dynamic imaging. Impact: A dynamic phantom to validate the sensitivity to assessing a spatially defined dynamic change in 23Na concentration, to mimic changes which may occur in muscle or brain functional sodium and apply NORDIC denoising to the data.