Left ventricular remodeling index predicts ventricular tachyarrhythmia in dilated cardiomyopathy with ejection fraction <35%

Motivation: To identify who may benefit from implantable cardioverter-defibrillator (ICD) in end-stage dilated cardiomyopathy (DCM). Goal(s): To explore the predictive value of a newly cardiac magnetic resonance (CMR) geometry parameter, LV remodeling index (LVRI), for ventricular tachyarrhythmia (VTA) in DCM patients with LVEF <35%. Approach: Consecutive DCM patients with LVEF <35% (n=271) were followed up for VTA, including sudden cardiac death or major ventricular arrhythmias. Competing risk regression analysis was used to evaluate the association of LVRI with VTA. Results: LVRI ≥7.5 is independently associated with lethal VTA in DCM patients with LVEF <35%. Impact: CMR-derived LVRI is associated with VTA in patients with nonischemic DCM with LVEF <35%, which may have clinical significance in guiding future implantable cardioverter-defibrillator implantation and improving risk stratification for DCM patients with LVEF <35%.