Advancing Psychosis Diagnosis in LMICs through Functional MRI Techniques

Motivation: The need to improve psychosis diagnosis in low- and middle-income countries (LMICs) arises from significant challenges in mental health care, including limited access to advanced diagnostic tools like functional MRI (fMRI). Goal(s): This project aims to evaluate the feasibility and effectiveness of implementing fMRI techniques for diagnosing psychosis in LMICs, focusing on identifying neurobiological markers. Approach: A systematic review of existing literature was conducted to assess fMRI applications and barriers to its adoption in LMIC contexts. Results: The review identified key fMRI biomarkers linked to psychosis but highlighted a lack of studies conducted specifically in LMICs, indicating a critical research gap. Impact: This systematic review highlights the urgent need for investment in neuroimaging infrastructure and training within LMICs to facilitate the integration of fMRI into clinical practice. Collaborative efforts between researchers, clinicians, and policymakers are essential to overcome barriers and improve mental health diagnostics for vulnerable populations.