Pancreatic Fat Fraction as a Biomarker for Type 2 Diabetes Mellitus in Obese Individuals: An MRI-Based Study
Motivation: To investigate the relationship between pancreatic fat deposition and the development of type 2 diabetes in obese individuals to understand its role in the pathogenesis of T2DM. Goal(s): To assess pancreatic fat in obese patients with T2DM and normal controls using MR Dixon Quant technique to elucidate the role of ectopic fat deposition in pancreatic progression of T2DM in obese individuals. Approach: Conducted a retrospective study using 3.0T MRI scans and MR Dixon Quant sequences to compare pancreatic fat fractions among obese T2DM patients, obese individuals without T2DM, and normal controls. Results: Pancreatic fat fraction (PFF) was significantly higher in T2DM with obesity. Impact: This research could guide early T2DM detection in obese patients and inform targeted therapeutic interventions.
Authors
- Yanhui Hao (ORCID: https://orcid.org/0000-0002-4616-0152)
- Yi Zhu (ORCID: https://orcid.org/0009-0005-1172-093X)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1749
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00