Mapping Brain Tissue Sodium Concentration in Cognitively Unimpaired Elderly Subjects: a 7T Sodium MRI study
Motivation: 23Na-MRI is an imaging technique to visualize cerebral sodium concentrations, serving as a potential estimate of brain metabolic state. Goal(s): To establish a map of normal brain tissue sodium concentration in cognitively unimpaired elderly subjects and its relation with age. Approach: 23Na-MRI acquisition on a ultra-high field 7T in a cohort of 80 healthy elderly subjects (50-80 years old). Results: Quantification parametric maps of tissue sodium concentration under ultra-high-field MRI conditions were created in elderly subjects and no strong association with age was found. Impact: 23Na-MRI imaging may be a sensitive tool to discriminate between physiological cerebral aging and decline during pathological processes.
Authors
- Michel Bottlaender (ORCID: https://orcid.org/0000-0002-2890-3653)
- Julien Lagarde (ORCID: https://orcid.org/0000-0002-2018-261X)
- Marie Sarazin (ORCID: https://orcid.org/0000-0002-5438-8392)
- Sandro Romanzetti (ORCID: https://orcid.org/0000-0001-8519-1309)
- Jörg B. Schulz (ORCID: https://orcid.org/0000-0002-8903-0593)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- Alexa Haeger (ORCID: https://orcid.org/0000-0003-2927-4016)
- Fawzi Boumezbeur (ORCID: https://orcid.org/0000-0002-3786-1053)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1789
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00