Improved Estimation of IVIM Parameters via Distortion and Motion Corrected DWI: Correlation with MaRIA Score in Pediatric Crohn's Disease

Motivation: Geometric distortions and motion artifacts in diffusion-weighted MRI (DW-MRI) limit its accuracy in assessing Crohn's disease (CD), affecting clinical evaluations. Goal(s): This study aimed to reduce distortion and motion artifacts to improve the accuracy of intravoxel incoherent motion (IVIM) parameters obtained from DW-MRI and examine their correlation with the magnetic resonance index of activity (MaRIA)-score. Approach: A dual-echo-EPI DW-MRI sequence with opposing encoding polarities was used for dynamic distortion correction. Motion correction was applied within and between volumes to address peristalsis and respiration. Results: The method enhanced IVIM-MaRIA correlations and reduced IVIM parameter variability, improving the reliability of DW-MRI in evaluating CD activity. Impact: Dual-echo EPI DW-MRI technique with dynamic distortion correction and motion compensation significantly improves the accuracy of Crohn's disease assessment, enhancing IVIM parameter estimation and correlation with disease activity scores, potentially leading to more precise diagnosis and monitoring of Crohn's disease.