A randomized controlled trial of statins to reduce inflammation in vertebrobasilar dissecting aneurysms (VBDAs) using vessel wall MRI
Motivation: Vertebrobasilar dissecting aneurysms (VBDAs) are a significant cause of stroke. Wall enhancement on vessel wall magnetic resonance imaging (VW-MRI) is a marker of inflammation. But VW-MRI has never been used in VBDAs for monitoring treatment response. Goal(s): To perform the first-ever prospective randomized controlled trial (the highest clinical evidence) on the effect of statins for changes in VBDAs wall enhancement. Approach: 40 patients with VBDAs were randomized 1:1 to either atorvastatin 20mg daily or not taken drug. VW-MRI was used to monitor wall enhancement and morphology changes over 6 months. Results: Statins decreased wall enhancement of VBDAs in a short term. Impact: Our results suggest VWI-MRI has great potential in future image-guided clinical trials to investigate novel treatment of VBDAs.
Authors
- Xinjian Yang (ORCID: https://orcid.org/0000-0001-7306-0125)
- Binbin Sui (ORCID: https://orcid.org/0000-0002-1052-6992)
- Chao Wang (ORCID: https://orcid.org/0009-0008-9901-4010)
- Yisen Zhang (ORCID: https://orcid.org/0000-0002-6685-0126)
- Mahmud Mossa‐Basha (ORCID: https://orcid.org/0000-0001-7798-8158)
- De‐Cai Tian (ORCID: https://orcid.org/0000-0002-5153-2491)
- Chengcheng Zhu (ORCID: https://orcid.org/0000-0001-6898-549X)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1922
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00