The role of incidental magnetization transfer in divided subtracted inversion recovery
Motivation: The dSIR sequence shows changes in mTBI patients that have not been seen previously that correspond to a small difference in T1. The motivation of the study is to understand the origin of the signal changes. Goal(s): The goal is to examine the effect of incidental magnetization on the dSIR signal in normal subjects and patients with mTBI. Approach: This is an in vivo clinical study using sequence parameters to vary the incidental magnetization transfer. Results: Results showed that normal white matter exhibited a strong dSIR signal (T1) reduction in response to MT irradiation whereas a patient with mTBI did not. Impact: This study identifies a plausible mechanism for dSIR signal changes in white matter that may lead to more efficient methods of detecting mTBI and hypoxic injuries.
Authors
- Gil Newburn
- Tracy R. Melzer (ORCID: https://orcid.org/0000-0003-0621-212X)
- Samantha J. Holdsworth (ORCID: https://orcid.org/0000-0002-2929-1169)
- Daniel Cornfeld (ORCID: https://orcid.org/0000-0002-7488-7834)
- Maryam Tayebi (ORCID: https://orcid.org/0000-0003-4911-3885)
- Graeme M. Bydder (ORCID: https://orcid.org/0000-0002-8468-0087)
- Miriam Scadeng (ORCID: https://orcid.org/0000-0002-9593-2956)
- Paul Condron (ORCID: https://orcid.org/0000-0002-5427-0634)
- Mark Bydder (ORCID: https://orcid.org/0000-0001-9210-0225)
- Nickolas J. Palmer
- Eryn Kwon (ORCID: https://orcid.org/0000-0003-4099-0080)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2018
- Primary Topic
- NMR spectroscopy and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00