Evaluation of 3DASL in early diagnosis and short-term prognosis of full-term neonatal hypoxic-ischemic encephalopathy (HIE)

Motivation: Early diagnosis and treatment remain challenging for hypoxic ischemic encephalopathy (HIE) in full-term infants. Goal(s): This study aimed to investigate the clinical value of 3DASL perfusion imaging for the early diagnosis and prognosis of HIE in full-term neonates. Approach: Cerebral blood flow (CBF) values of bilateral frontal lobes, basal ganglia, thalamus were compared between the HIE groups with good and adverse outcomes and healthy controls. Results: The HIE groups with the adverse outcome showed significant decreased CBF values in the frontal lobes but significantly increased CBF values in basal ganglia and thalamus as compared to the good outcome and control groups. Impact: We observed significant group differences between HIE neonates with good and adverse outcomes and healthy controls. 3DASL could reflect abnormal changes of cerebral perfusion in HIE infants and demonstrated the clinical value for early diagnosis and diagnosis of HIE.