Initial Impression of MR Guided PET Reconstruction in Detecting Focal Cortical Hypometabolism in Epilepsy Patients

Motivation: Detecting abnormalities such as focal cortical dysplasia on FDG PET is challenging due to limited resolution and patient motion. Using anatomical information from MR images in PET reconstruction can improve the quality of PET images and likely leads to better detection. Goal(s): Demonstrating the impact and potential benefit of MR-guided (MRG) PET Reconstruction for the detection and localization of focal cortical hypometabolism. Approach: Compare the image quality and visualization of focal cortical hypometabolism between conventional and MR-guided PET reconstruction in a group of epilepsy patients scanned on a 3.0T PET MR retrospectively Results: MR-guided PET reconstruction shows focal cortical hypometabolism more clearly Impact: MR-guided PET reconstruction allows better visualization of focal cortical hypometabolism which may lead to improved diagnosis of epilepsy.