Visualization of Vasoactive Treatment by Hyperpolarized Xenon-129 MRSI and Cardiogenic Oscillations

Motivation: The invasive nature of cardiopulmonary hemodynamic assessments leaves a gap in accessibility of diagnostic tools in fragile chronically ill patients with pulmonary hypertension. Goal(s): Understanding the complex interplay between hyperpolarized (HP) xenon-129 MRSI and cardiopulmonary hemodynamics, in non-invasive assessment of disease progression and treatment response. Approach: Vasoactive interventions were conducted on seven pigs, comparing invasive cardiopulmonary measurements with HP xenon-129 MRSI dissolved-phase and cardiogenic oscillations. Results: Interventions successfully caused vasoactive hemodynamic changes, detectable by HP 129Xe MRSI. An inverse proportional correlation was found between mPAP and oscillation amplitude, RBC AUC and RBC:mem. Impact: Hyperpolarized 129Xe MRSI enables non-invasive monitoring of pulmonary hypertension, facilitating early diagnosis and precise hemodynamic assessment. This approach supports optimized treatment, reduces hospitalizations, and enhances quality of life and survival in chronically ill patients.