Multiparametric 3D-MRE for Longitudinal Monitoring of Disease Progression in CHB Patients, With or Without Treatment

Motivation: Three-dimensional magnetic resonance elastography (3D-MRE) can detect necroinflammation and fibrosis in chronic hepatitis B (CHB) patients. However, few studies have examined the ability of 3D-MRE to monitor liver changes in CHB patients, both with and without antiviral treatment. Goal(s): To develop a non-invasive follow-up method using 3D-MRE for both treated and untreated CHB patients. Approach: Cohen's Kappa test compared the agreement between disease progression diagnosed by pathology or clinical criteria and that diagnosed by MRE. Spearman correlation analysis was performed between changes in 3D-MRE and liver histology or clinical indicators during follow-up. Results: 3D-MRE effectively monitors disease progression in CHB patients during follow-up. Impact: 3D-MRE offers a non-invasive biomarker for longitudinal monitoring in CHB patients.