Multiparametric MRI Study Changes of Obese Patients with Type 2 Diabetes or Prediabetes Undergoing Bariatric Surgery.

Motivation: Bariatric surgery induces weight loss and Type 2 diabetes remission, but the mechanism/changes across insulin sensitive organs are unclear. Goal(s): To quantify changes in liver, spleen, pancreas and Subcutaneous Adipose Tissue (SAT). Approach: Multiparametric MRI of fat fraction (FF), T2* and volume, T1 and T2, B1 and B0 at four timepoints before and after bariatric surgery. Results: A significant reduction was seen in liver and spleen volume, liver T1, and liver and spleen FF and SAT which correlated with reduced Body Mass Index (BMI)/Body Surface Area (BSA). BSA negatively correlated with liver B1 leading to an overestimation in measured liver T2. Impact: MRI is used to assess changes in liver, spleen and pancreas volume, fat, relaxometry (T1, T2* and T2) and subcutaneous fat before and after bariatric surgery. These measures serve as markers for longitudinal and cross-sectional assessment of response to surgery.