Evaluating MRI Response in Breast Tumours Treated with Radiotherapy – Can Apparent Diffusion Co-efficient (ADC) Predict Long Term Response?
Motivation: Research on how primary breast tumours in situ respond to radiotherapy is very limited, though increasingly relevant as neo-adjuvant radiotherapy trials expand, requiring accurate and sensitive monitoring of therapy response. Goal(s): To evaluate MRI response in breast tumours treated with radiotherapy and assess whether ADC values or their changes predict long-term outcomes. Approach: Twenty-five patients underwent radiotherapy to in-situ breast tumours with the aim of long-term control. CE-DW-MRI was performed at baseline and 2W, 6M and 12M post-radiotherapy. Results: Early ADC changes at 2-weeks post-radiotherapy correlated more strongly with long-term response than later ADC changes. Impact: Early assessment of ADC on DW-MRI after radiotherapy treatment could predict long term responses in breast tumours. This could allow future personalisation of radiotherapy doses based on baseline ADC values of tumours.
Authors
- Archana Seth (ORCID: https://orcid.org/0009-0005-9743-4941)
- Navita Somaiah (ORCID: https://orcid.org/0000-0003-4609-0518)
- Purvi Haria (ORCID: https://orcid.org/0000-0003-1588-9722)
- Matthew Blackledge (ORCID: https://orcid.org/0000-0001-8117-9003)
- Megan A. Morris (ORCID: https://orcid.org/0000-0002-0386-992X)
- Aditi Chandra (ORCID: https://orcid.org/0000-0002-2053-163X)
- Seyed Hamid Salehi (ORCID: https://orcid.org/0000-0002-0830-2770)
- M Bárta
- Philip Borg (ORCID: https://orcid.org/0000-0001-9466-9482)
- Emily Durie (ORCID: https://orcid.org/0000-0002-3474-0125)
- Nuala Healy (ORCID: https://orcid.org/0000-0002-0620-6056)
- Nina Tunariu (ORCID: https://orcid.org/0000-0001-6656-3699)
- Meng‐Xing Tang (ORCID: https://orcid.org/0000-0001-7686-425X)
- Steven L. Allen (ORCID: https://orcid.org/0000-0002-3482-3182)
- C Rakesh
- Shalini Sahu
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2892
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00