MRI Evaluation of Choroid Plexus Volume Changes in Mild Cognitive Impairment

Motivation: The choroid plexus (CP) plays a significant role in Alzheimer's disease (AD) pathophysiology, but its imaging characteristics in mild cognitive impairment (MCI) are unclear. Goal(s): To investigate the imaging features of CP volume in amnestic and vascular MCI (aMCI and vMCI) and assess their clinical significance. Approach: Segmented brain regions on T1-weighted MRI images to compare CP volume with cognitive function and hippocampal volume. Results: Standardized CP volume was significantly larger in aMCI and vMCI groups compared to healthy controls (aMCI vs. HC: P = 0.0247; vMCI vs. HC: P = 0.006). Impact: Discovering that the choroid plexus volume is larger in mild cognitive impairment suggests it could be an MRI marker for early memory issues, aiding in brain disease research like Alzheimer's and helping develop new treatments.